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StressChron
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  • Maternally deposited and early life (stress induced) de novo synthesis of glucocorticoids by the Hypothalamic-Pituitary-Interrenal axis using carp (Cyprinus carpio) as a model: the effect of cortisol and its endogenous phase I metabolites on glucocorticoid (pre)receptor regulation in brain and bone

Maternally deposited and early life (stress induced) de novo synthesis of glucocorticoids by the Hypothalamic-Pituitary-Interrenal axis using carp (Cyprinus carpio) as a model: the effect of cortisol and its endogenous phase I metabolites on glucocorticoid (pre)receptor regulation in brain and bone

StressChron Framework:

Project code 146
Acronym BRAINBONE
Role Coordinator
Research area Unravelling the fundamentals of glucocorticoid actions across vertebrates
Research topic Chronic stress, target glucocorticoid receptor profiles and ligand binding kinetics
Vertebrate Fish
Species Carp (Cyprinus carpio)

Abstract:

This study focuses on the influence of maternally deposited and early life (stress induced) de novo synthesis of glucocorticoids by the Hypothalamic-Pituitary-Interrenal axis using carp (Cyprinus carpio) as a model: the effect of cortisol and its endogenous phase I metabolites on glucocorticoid (pre-)receptor regulation in brain and bone.

Specifics:

Keywords: fish, HPI, glucocorticoid, stress, bone

Funding: Internal

Status: On-going

Consortium:

Ghent University, Belgium (Aerts J, Lens L, Briels N, Carbone M)

Flanders Research Institute for Agriculture, Fisheries and Food, Belgium (Aerts J)

Output:

none at present

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