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StressChron Framework:

Project code 144
Acronym GIO
Role Coordinator
Research area Unravelling the fundamentals of glucocorticoid actions across vertebrates
Research topic Glucocorticoid-mediated bone (de)formation
Vertebrate Fish, Human
Species Carp (Cyprinus carpio), human cell types (Homo sapiens)


This study focuses on the influence of long-term elevated levels of ‘natural’ de novo synthesized glucocorticoids by the Hypothalamic-Pituitary-Interrenal (fish) or -Adrenal (human) axis (as seen in chronic stress) using fish scales of carp (Cyprinus carpio) and human osteoblasts and osteoclast cell lines as a model in framework of glucocorticoid-induced-osteoporosis, a pathology observed in individuals chronically exposed to excessive amounts of ‘synthetic’ glucocorticoids used as therapeutic agent.


Keywords: fish, human, stress, glucocorticoids, glucocorticoid-induced-osteoporosis

Funding: Internal

Status: On-going


Ghent University, Belgium (Aerts J, Briels N)

Flanders Research Institute for Agriculture, Fisheries and Food, Belgium (Aerts J)


None at present

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