|Research area||Unravelling the fundamentals of glucocorticoid actions across vertebrates|
|Research topic||Glucocorticoid-mediated bone (de)formation|
|Species||Carp (Cyprinus carpio), human cell types (Homo sapiens)|
This study focuses on the influence of long-term elevated levels of ‘natural’ de novo synthesized glucocorticoids by the Hypothalamic-Pituitary-Interrenal (fish) or -Adrenal (human) axis (as seen in chronic stress) using fish scales of carp (Cyprinus carpio) and human osteoblasts and osteoclast cell lines as a model in framework of glucocorticoid-induced-osteoporosis, a pathology observed in individuals chronically exposed to excessive amounts of ‘synthetic’ glucocorticoids used as therapeutic agent.
Keywords: fish, human, stress, glucocorticoids, glucocorticoid-induced-osteoporosis
Ghent University, Belgium (Aerts J, Briels N)
Flanders Research Institute for Agriculture, Fisheries and Food, Belgium (Aerts J)
None at present